Uterine leiomyoma are benign mesenchymal solid tumors originating from smooth muscle cells during the fertile stage of life. There are various factors that are associated to underlie the development and incidence of these myomas. A number of chromosomal alterations and gene mutations are responsible for the leading cause of uterine leiomyoma: the most common of which include translocation on chromosome 7 and translocation on chromosome 12 targeting HMGA and RAD51L1 mutation.